Lnc(ing) interferon production and action
نویسندگان
چکیده
منابع مشابه
Lncing protein translation to metastasis.
Long noncoding RNAs (lncRNAs) are a novel class of regulators that play crucial roles in development and disease. Here we highlight the findings by Huang and colleagues that a regulatory lncRNA (treRNA) acts as a scaffold for a new ribonucleic protein complex that inhibits translation of E-cadherin and promotes cell invasion. This work underscores the potential importance of lncRNAs in cancer m...
متن کاملMechanism of Interferon Action
The double-stranded RNA (dsRNA)-dependent protein kinase which catalyzes the phosphorylation of ribosome-associated protein Pl and the a subunit of eukaryotic protein synthesis initiation factor 2 (eIF-2) was purified and characterized from mouse fibroblast L929 cells treated with either natural or recombinant interferon and from untreated cells. The dsRNA-dependent Pl/eIF-2a kinase was purifie...
متن کاملCirculating Interferon Production
A radiobiological study of circulating interferon production in the mouse was undertaken in the hope of elucidating the site(s) of circulating interferon production. After total body X-irradiation of the animals, different radiosensitivities of circulating interferon production were observed with different viral inducers. Myxovirus-induced circulating interferon production was especially radios...
متن کاملCellular Mechanisms of Interferon Production
Rabbit kidney cell cultures stimulated with either double-stranded polyinosinate-polycytidylate (poly I:poly C) or with ultraviolet-irradiated Newcastle disease virus (UV-NDV) produce two types of interferon response, designated "early" and "late," respectively. The early response is suppressed by inhibitors of RNA or protein synthesis and is therefore thought to represent de novo synthesis of ...
متن کاملLncing epigenetic control of transcription to cardiovascular development and disease.
Transcriptional and epigenetic regulation is critical for proper heart development, cardiac homeostasis, and pathogenesis. Long noncoding RNAs have emerged as key components of the transcriptional regulatory pathways that govern cardiac development as well as stress response, signaling, and remodeling in cardiac pathologies. Within the past few years, studies have identified many long noncoding...
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ژورنال
عنوان ژورنال: Cell Research
سال: 2019
ISSN: 1001-0602,1748-7838
DOI: 10.1038/s41422-019-0207-y